Archive for the ‘Levitra’ Category
Sunday, March 2nd, 2008
The long-term safety of tadalafil has been assessed in 1173 patients
enrolled in an ongoing, international, open-label study. Of the patients
enrolled, most (870) had been exposed to 10 or 20 mg of tadalafil daily
for at least 1 yr, with 991 being exposed to these dosages for more than
6 mo. Adverse events experienced by patients in the [...]
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Sunday, March 2nd, 2008
Common extrinsic factors appear to exert no influence on the pharmacokinetics
of tadalafil. For example, in a clinical pharmacology study
conducted in 18 healthy subjects, on the effect of food on tadalafil absorption,
the mean plasma tadalafil concentration was similar among subjects
who received a single 20-mg dose of tadalafil after eating a high-fat
meal and among subjects who fasted, [...]
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Wednesday, February 27th, 2008
PDE5 is found in the smooth muscle cells of systemic arteries and veins,
and inhibitors of this isoenzyme act as mild vasodilators. Through relaxation
of vascular smooth muscle, the hemodynamic effects of the PDE5
inhibitors can have major implications for the treatment of ED, especially
in patients with comorbid cardiovascular conditions, such as coronary
artery disease (CAD) and hypertension. Because [...]
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Wednesday, February 27th, 2008
Study results consistently show that tadalafil treatment has little effect
on systemic arterial pressure. This is supported by data reported on more
than 5700 subjects treated with tadalafil in more than 22 clinical trials. One study, conducted in 80 healthy subjects, showed that single
doses of 10 or 20 mg of tadalafil have only modest effects on systolic [...]
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Wednesday, February 27th, 2008
Patients receiving tadalafil would appear to be at no greater risk for
cardiovascular-related side effects, including flushing, dizziness, hypertension, and syncope, than are patients taking placebo because the incidence
of these adverse events is low (0.1–3.7%) and not statistically significantly
different among the two patient populations. Importantly,
the rate of myocardial infarction among patients taking tadalafil (0.43 per
100 patient-years) [...]
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Wednesday, February 27th, 2008
Because ED and CAD may often coexist, a study was conducted in men
with stable CAD who demonstrated ischemia during a screening exercise
test to examine the effects of tadalafil on physical exercise at a workload
similar to that experienced during sexual activity. The study was a
randomized, double-blind, two-way crossover design in which patients
(aged 53–75 yr) received 10 [...]
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Wednesday, February 27th, 2008
The effect of a single 100-mg dose of tadalafil on QT interval, which
represents ventricular depolarization and repolarization, was evaluated at
the time of peak tadalafil concentration in a randomized, double-blind,
placebo- and active (intravenous ibutilide)-controlled crossover study in
90 healthy males 18 to 53 yr of age. The mean change in QTc (Fridericia
QT correction) for tadalafil, relative to [...]
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Tuesday, February 26th, 2008
ED is a frequent complication of radical prostatectomy. Despite improvements
in surgical techniques used in prostatectomy, trauma to neurovascular
bundles leaves many patients with ED. In fact, more than 50% of patients
who undergo prostatectomy procedures will have ED. In one study, the
effects of tadalafil were examined in men who had developed ED after
bilateral nerve-sparing radical retropubic prostatectomy [...]
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Tuesday, February 26th, 2008
In one study, significantly greater penile rigidity (as measured by
RigiScan® [Timm Medical Technologies, Eden Prairie, MN] and compared
with placebo) was observed at an average of 45 min after subjects took a
single 10-mg dose of tadalafil. Achievement of erection was observed as
early as 16 min after subjects took a single 20-mg dose.
Although tadalafil has a relatively [...]
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Tuesday, February 26th, 2008
Pharmacokinetic studies conducted in healthy subjects show that
tadalafil is rapidly absorbed, with mean peak plasma levels observed
between 30 min and 6 h (median time of 2 h) after single oral-dose
administration. Tadalafil exhibits linear pharmacokinetics
over the dosage range of 2.5 to 20 mg, and steady-state plasma concentrations
are attained within 5 d of once-daily dosing, with exposure [...]
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