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Structure and function of ‘ PDE5

Tuesday, August 5th, 2008

PDE5 is a dimeric enzyme that is composed of two identical 100 kD proteins. There are four known isoforms of PDE5 ( PDE5A 1-4 ) ACC . No : NM - 03343I : these isoforms are products of a single gene and are formed by alternative splicing of mRNA . The enzymatic characteris- tics of the PDE5A1-3 appear to [...]

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Viagra and the Perfect Cure

Tuesday, August 5th, 2008

Viagra is a recent invention , but sex is not . And for as long as humans have engaged in sexual activity , there has been impotence . The word impotence first appeared in the fifteenth century , but today it has been abandoned in politically correct circles in favor of the term erectile dysfunction [...]

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Structure and function of ‘ PDE5

Sunday, March 23rd, 2008

PDE5 is a dimeric enzyme that is composed of two identical 100 kD proteins. There are four known isoforms of PDE5 ( PDE5A 1-4 ) ACC . No : NM - 03343I : these isoforms are products of a single gene and are formed by alternative splicing of mRNA . The enzymatic characteris- tics of [...]

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Mechanisrn of action of sildenafil

Sunday, March 23rd, 2008

Sildenafil is a competitive and reversible inhibitor of cGMP hydrolysis by the catalytic site of PDE5 . Sildenafil is an analog of cGMP , the PDE5 substrate , but PDE5 has - 1000-fold higher affinity for sildenafil than for cGMP. The purine ring of cGMP is mimicked by similar components in sildenafil , and this [...]

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Sildenafil. Modulation of cellular cGMP level

Sunday, March 23rd, 2008

In all cells , the level of cGMP is primarily determined by the relative rates of cGMP synthesis by the GCs and its breakdown by PDEs. An imbal- ance between the synthesis ( e . g ., decreased release of nitric oxide due to penile nerve deterioration or endothelial cell damage ) and breakdown of [...]

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Sildenafil , pharmacology of a highly selective PDES inhibitor

Sunday, March 23rd, 2008

Sharron H . Francis and Jackie D . Corkin Light Hall Room 702 , Department of Molecular Physiology & Biophysics , Vanderbilt University School of Medicine , Nashville , TN 37232-0615 , ( ISA Introduction The roles of cAMP ( cyclic AMP ) and cGMP ( cyclic GMP ) in regulating myr- iad physiological and pathophysiological [...]

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Viagra and the Perfect Cure

Sunday, March 23rd, 2008

Viagra is a recent invention , but sex is not . And for as long as humans have engaged in sexual activity , there has been impotence . The word impotence first appeared in the fifteenth century , but today it has been abandoned in politically correct circles in favor of the term erectile dysfunction [...]

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Viagra (Introduction) part 3

Sunday, March 23rd, 2008

This is a book about real people . The men and women who pass through my office share intimate details of their lives that would otherwise never see the light of day were it not for this book . Nat- urally , names and details have been changed in order to preserve privacy , and […]

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Viagra (sildenafil)

Wednesday, February 20th, 2008

Viagra is used for: Treating erectile dysfunction (ED). It may also be used for other conditions as determined by your doctor. Viagra is a phosphodiesterase inhibitor. It works by helping to increase blood flow into the penis during sexual stimulation. This helps you to achieve and maintain an erection. Do NOT use Viagra if: you are allergic [...]